TY - JOUR U1 - Wissenschaftlicher Artikel A1 - Wenz, Annika A1 - Janke, Katharina A1 - Hoch, Eva A1 - Tovar, Günter A1 - Borchers, Kirsten A1 - Kluger, Petra T1 - Hydroxyapatite-modified gelatin bioinks for bone bioprinting JF - Bionanomaterials : journal of functional materials, biomechanics, and tissue engineering N2 - In bioprinting approaches, the choice of bioink plays an important role since it must be processable with the selected printing method, but also cytocompatible and biofunctional. Therefore, a crosslinkable gelatin-based ink was modified with hydroxyapatite (HAp) particles, representing the composite buildup of natural bone. The inks’ viscosity was significantly increased by the addition of HAp, making the material processable with extrusion-based methods. The storage moduli of the formed hydrogels rose significantly, depicting improved mechanical properties. A cytocompatibility assay revealed suitable ranges for photoinitiator and HAp concentrations. As a proof of concept, the modified ink was printed together with cells, yielding stable three-dimensional constructs containing a homogeneously distributed mineralization and viable cells. KW - additive manufacturing KW - mineralization KW - osteoblast differentiation KW - tissue engineering Y1 - 2016 SN - 2193-0651 SS - 2193-0651 U6 - https://doi.org/10.1515/bnm-2015-0018 DO - https://doi.org/10.1515/bnm-2015-0018 VL - 17 IS - 3-4 SP - 179 EP - 184 S1 - 6 PB - De Gruyter CY - Berlin ER -