TY - JOUR U1 - Wissenschaftlicher Artikel A1 - Frey, Kerstin A1 - Fischer, Alena A1 - Krastev, Rumen A1 - Kemkemer, Ralf T1 - CurvChip - chip platform for investigating cell responses to curved surface features JF - Current directions in biomedical engineering N2 - Surface topographies are often discussed as an important parameter influencing basic cell behavior. Whereas most in vitro studies deal with microstructures with sharp edges, smooth, curved microscale topographies might be more relevant concerning in-vivo situations. Addressing the lack of highly defined surfaces with varying curvature, we present a topography chip system with 3D curved features of varying spacing, curvature radii as well as varying overall dimensions of curved surfaces. The CurvChip is produced by low-cost photolithography with thermal reflow, subsequent (repetitive) PDMS molding and hot embossing. The platform facilitates the systematic in-vitro investigation of the impact of substrate curvature on cell types like epithelial, endothelial, smooth muscle cells, or stem cells. Such investigations will not only help to further understand the mechanism of curvature sensation but may also contribute to optimize cell-material interactions in the field of regenerative medicine. KW - photolithography KW - thermal reflow KW - topography with defined 3D curvature KW - chip platform Y1 - 2018 UN - https://nbn-resolving.org/urn:nbn:de:bsz:rt2-opus4-21505 SN - 2364-5504 SS - 2364-5504 U6 - https://doi.org/10.1515/cdbme-2018-0108 DO - https://doi.org/10.1515/cdbme-2018-0108 VL - 4 IS - 1 SP - 453 EP - 456 S1 - 4 PB - De Gruyter CY - Berlin ER -