TY - JOUR U1 - Zeitschriftenartikel, wissenschaftlich - begutachtet (reviewed) A1 - Schuhmacher, Alexander A1 - Wilisch, Lucas A1 - Kuss, Michael A1 - Kandelbauer, Andreas A1 - Hinder, Markus A1 - Gassmann, Oliver T1 - R&D efficiency of leading pharmaceutical companies : a 20-year analysis JF - Drug discovery today N2 - Comparative analysis of the R&D efficiency of 14 leading pharmaceutical companies for the years 1999–2018 shows that there is a close positive correlation between R&D spending and the two investigated R&D output parameters, approved NMEs and the cumulative impact factor of their publications. In other words, higher R&D investments (input) were associated with higher R&D output. Second, our analyses indicate that there are "economies of scale" (size) in pharmaceutical R&D. KW - pharmaceutical R&D KW - R&D efficiency KW - economies of scale KW - big pharma Y1 - 2021 SN - 1359-6446 SS - 1359-6446 U6 - https://doi.org/10.1016/j.drudis.2021.05.005 DO - https://doi.org/10.1016/j.drudis.2021.05.005 VL - 26 IS - 8 SP - 1784 EP - 1789 S1 - 6 PB - Elsevier CY - Amsterdam ER -