TY  - JOUR
U1  - Zeitschriftenartikel, wissenschaftlich - begutachtet (reviewed)
A1  - Elnathan, Roey
A1  - Holle, Andrew
A1  - Young, Jennifer
A1  - George, Marina
A1  - Omri, Heifler
A1  - Goychuk, Andriy
A1  - Frey, Erwin
A1  - Kemkemer, Ralf
A1  - Spatz, Joachim
A1  - Kosloff, Alon
A1  - Patolsky, Fernando
A1  - Voelcker, Nicolas
T1  - Optically transparent vertical silicon nanowire arrays for live-cell imaging
JF  - Journal of nanobiotechnology
N2  - Programmable nano-bio interfaces driven by tuneable vertically configured nanostructures have recently emerged as a powerful tool for cellular manipulations and interrogations. Such interfaces have strong potential for ground-breaking advances, particularly in cellular nanobiotechnology and mechanobiology. However, the opaque nature of many nanostructured surfaces makes non-destructive, live-cell characterization of cellular behavior on vertically aligned nanostructures challenging to observe. Here, a new nanofabrication route is proposed that enables harvesting of vertically aligned silicon (Si) nanowires and their subsequent transfer onto an optically transparent substrate, with high efficiency and without artefacts. We demonstrate the potential of this route for efficient live-cell phase contrast imaging and subsequent characterization of cells growing on vertically aligned Si nanowires. This approach provides the first opportunity to understand dynamic cellular responses to a cell-nanowire interface, and thus has the potential to inform the design of future nanoscale cellular manipulation technologies.
KW  - glass substrate
KW  - silicon
KW  - live-cell phase-contrast imaging
KW  - cell–material interface
KW  - nanowires
Y1  - 2021
UN  - https://nbn-resolving.org/urn:nbn:de:bsz:rt2-opus4-33450
SN  - 1477-3155
SS  - 1477-3155
U6  - https://doi.org/10.1186/s12951-021-00795-7
DO  - https://doi.org/10.1186/s12951-021-00795-7
VL  - 19
SP  - 6
S1  - 6
PB  - Springer
CY  - London
ER  -