@article{WenzJankeHochetal.2016, author = {Wenz, Annika and Janke, Katharina and Hoch, Eva and Tovar, G{\"u}nter and Borchers, Kirsten and Kluger, Petra}, title = {Hydroxyapatite-modified gelatin bioinks for bone bioprinting}, journal = {Bionanomaterials : journal of functional materials, biomechanics, and tissue engineering}, volume = {17}, number = {3-4}, issn = {2193-0651}, doi = {10.1515/bnm-2015-0018}, institution = {Life Sciences}, pages = {179 -- 184}, year = {2016}, abstract = {In bioprinting approaches, the choice of bioink plays an important role since it must be processable with the selected printing method, but also cytocompatible and biofunctional. Therefore, a crosslinkable gelatin-based ink was modified with hydroxyapatite (HAp) particles, representing the composite buildup of natural bone. The inks' viscosity was significantly increased by the addition of HAp, making the material processable with extrusion-based methods. The storage moduli of the formed hydrogels rose significantly, depicting improved mechanical properties. A cytocompatibility assay revealed suitable ranges for photoinitiator and HAp concentrations. As a proof of concept, the modified ink was printed together with cells, yielding stable three-dimensional constructs containing a homogeneously distributed mineralization and viable cells.}, language = {en} }