@article{AthanasopuluCaltzidouSekishitaetal.2020,
  author    = {Athanasopulu, Kiriaki and Caltzidou, Dimitra and Sekishita, Asuka and Kutuzova, Larysa and Lorenz, G{\"u}nter and Tanaka, Masaru and Kemkemer, Ralf},
  title     = {Sulfated hyaluronan coating of polyurethanebased implant materials},
  journal   = {Current directions in biomedical engineering},
  volume    = {6},
  number    = {3},
  issn      = {2364-5504},
  doi       = {10.1515/cdbme-2020-3115},
  institution = {Life Sciences},
  pages     = {20203115},
  year      = {2020},
  abstract  = {Thermoplastic polycarbonate urethane elastomers (TPCU) are potential implant materials for treating degenerative joint diseases thanks to their adjustable rubber-like properties, their toughness, and their durability. We developed a water-containing high-molecular-weight sulfated hyaluronic acid-coating to improve the interaction of TPCU with the synovial fluid. It is suggested that trapped synovial fluid can act as a lubricant that reduces the friction forces and thus provides an enhanced abrasion resistance of TPCU implants. Aims of this work were (i) the development of a coating method for novel soft TPCU with high-molecular sulfated hyaluronic acid to increase the biocompatibility and (ii) the in vitro validation of the functionalized TPCUs in cell culture experiments.},
  language  = {en}
}