TY  - JOUR
U1  - Zeitschriftenartikel, wissenschaftlich - begutachtet (reviewed)
A1  - Shahriari-Khalaji, Mina
A1  - Hu, Gaoquan
A1  - Chen, Lin
A1  - Cao, Zhangjun
A1  - Andreeva, Tonya
A1  - Xiong, Xin
A1  - Krastev, Rumen
A1  - Hong, Feng
T1  - Functionalization of aminoalkylsilane-grafted bacterial nanocellulose with ZnO-NPs-doped pullulan electrospun nanofibers for multifunctional wound dressing
JF  - ACS biomaterials science & engineering
N2  - High moisture permeability, excellent mechanical properties in a wet state, high water-holding capability, and high exudate absorption make bacterial nanocellulose (BNC) a favorable candidate for biomedical device production, especially wound dressings. The lack of antibacterial activity and healing-promoting ability are the main drawbacks that limit its wide application. Pullulan (Pul) is a nontoxic polymer that can promote wound healing. Zinc oxide nanoparticles (ZnO-NPs) are well-known as a safe antibacterial agent. In this study, aminoalkylsilane was chemically grafted on a BNC membrane (A-g-BNC) and used as a bridge to combine BNC with Pul-ZnO-NPs hybrid electrospun nanofibers. FTIR results confirmed the successful production of A-g-BNC/Pul-ZnO. The obtained dressing demonstrated blood clotting performance better than that of BNC. The dressing showed an ability to release ZnO, and its antibacterial activity was up to 5 log values higher than that of BNC. The cytotoxicity of the dressing toward L929 fibroblast cells clearly showed safety due to the proliferation of fibroblast cells. The animal test in a rat model indicated faster healing and re-epithelialization, small blood vessel formation, and collagen synthesis in the wounds covered by A-g-BNC/Pul-ZnO. The new functional dressing, fabricated with a cost-effective and easy method, not only showed excellent antibacterial activity but could also accelerate wound healing.
KW  - antibacterial activity
KW  - materials
KW  - anatomy
KW  - nanofibers
KW  - bacteria
Y1  - 2021
SN  - 2373-9878
SS  - 2373-9878
U6  - https://doi.org/10.1021/acsbiomaterials.1c00444
DO  - https://doi.org/10.1021/acsbiomaterials.1c00444
VL  - 7
IS  - 8
SP  - 3933
EP  - 3946
S1  - 14
PB  - American Chemical Society
CY  - Washington, DC
ER  -