TY - JOUR U1 - Zeitschriftenartikel, wissenschaftlich - begutachtet (reviewed) A1 - Jung, Ole A1 - Barbeck, Mike A1 - Fan, Lu A1 - Korte, Fabian A1 - Zhao, Cuifeng A1 - Krastev, Rumen A1 - Pantermehl, Sven A1 - Xiong, Xin T1 - In vitro and ex vivo analysis of collagen foams for soft and hard tissue regeneration JF - In vivo : international journal of experimental and clinical pathophysiology and drug research N2 - Background/Aim: The aim of this study was the conception, production, material analysis and cytocompatibility analysis of a new collagen foam for medical applications. Materials and Methods: After the innovative production of various collagen sponges from bovine sources, the foams were analyzed ex vivo in terms of their structure (including pore size) and in vitro in terms of cytocompatibility according to EN ISO 10993-5/-12. In vitro, the collagen foams were compared with the established soft and hard tissue materials cerabone and Jason membrane (both botiss biomaterials GmbH, Zossen, Germany). Results: Collagen foams with different compositions were successfully produced from bovine sources. Ex vivo, the foams showed a stable and long-lasting primary structure quality with a bubble area of 1,000 to 2,000 μm2. In vitro, all foams showed sufficient cytocompatibility. Conclusion: Collagen sponges represent a promising material for hard and soft tissue regeneration. Future studies could focus on integrating and investigating different additives in the foams. KW - collagen KW - collagen foam KW - tissue regeneration KW - macrophages KW - vascularization KW - soft tissue KW - hard tissue Y1 - 2021 UN - https://nbn-resolving.org/urn:nbn:de:bsz:rt2-opus4-35015 SN - 1791-7549 SS - 1791-7549 U6 - https://doi.org/10.21873/invivo.12536 DO - https://doi.org/10.21873/invivo.12536 VL - 35 IS - 5 SP - 2541 EP - 2549 S1 - 9 PB - IIAR CY - Kapandriti, Attiki ER -