TY  - JOUR
U1  - Zeitschriftenartikel, wissenschaftlich - begutachtet (reviewed)
A1  - Ullah, Sadeeq
A1  - Khan, Shahin
A1  - Ren, Yanru
A1  - Zhang, Xu
A1  - Qin, Meng
A1  - Xiong, Xin
A1  - Krastev, Rumen
A1  - Jan, Amin
A1  - Liu, Luo
A1  - Yuan, Qipeng
T1  - Near-infrared laser 808-nm excitable palladium nano-dots loaded on graphene oxide hybrid for the antibacterial activity
JF  - Applied organometallic chemistry
N2  - Escherichia coli (E. coli) is considered the most common life-threatening infectious bacteria in our daily life and poses a major challenge to human health. However, antibiotics frequently overused and misused has triggered increased multidrug resistance, hinders therapeutic outcomes, and causes higher mortalities. Herein, we addressed near-infrared (NIR) laser-excited human serum albumin (HSA) mediated graphene oxide loaded palladium nano-dots (HSA-GO-Pd) that can effectively combat Gram-negative E. coli in vitro. NIR laser-excited designed hybrid material highly generates singlet oxygen and hydroxyl radical by electron spin-resonance (ESR) analysis. Transmission electron microscope (TEM) images show small spherical sizes PdNPs on the surface of GO nano-sheets. The zeta (ζ) potential study indicates that in an aqueous medium, the average PdNPs size and surface capped charge comes from human body protein (HSA), HSA-GO-Pd is 5–8 nm, and +25 mV, respectively. The spectroscopic characterization reveals that in the synthesized HSA-GO-Pd nanocomposite, PdNPs successfully well-dispersed decorated on the surface of graphene oxide. The as-synthesized HSA-GO-Pd shows excellent antibacterial activity against gram-negative pathogen by killing 95% bacteria within 5 h. HSA-GO-Pd having very biocompatible and shows significant antibacterial activities. Owing to their intense photothermal conversation potential, low toxicity to normal cells, the as-addressed hybrid (HSA-GO-Pd) combined with NIR-irradiation will catch up valuable insight into the effective ablation of pathogenic bacteria.
KW  - bacterial therapy
KW  - characterization
KW  - graphene oxide
KW  - near-infrared
KW  - palladium nano-dots
Y1  - 2021
U6  - https://doi.org/10.1002/aoc.6380
DO  - https://doi.org/10.1002/aoc.6380
VL  - 35
IS  - 11
SP  - 11
S1  - 11
PB  - Wiley
CY  - New York
ER  -