TY  - JOUR
U1  - Zeitschriftenartikel, wissenschaftlich - begutachtet (reviewed)
A1  - Wang, Pei
A1  - Kankala, Ranjith
A1  - Chen, Biaoqi
A1  - Zhang, Yang
A1  - Zhu, Mingzhi
A1  - Li, Xuemei
A1  - Long, Ruimin
A1  - Yang, Dayun
A1  - Krastev, Rumen
A1  - Wang, Shibin
A1  - Xiong, Xin
A1  - Liu, Yuangang
T1  - Cancer cytomembrane-cloaked Prussian blue nanoparticles enhance the efficacy of mild-temperature photothermal therapy by disrupting mitochondrial functions of cancer cells
JF  - ACS applied materials & interfaces
N2  - Despite its success against cancer, photothermal therapy (PTT) (>50 °C) suffers from several limitations such as triggering inflammation and facilitating immune escape and metastasis and also damage to the surrounding normal cells. Mild-temperature PTT has been proposed to override these shortcomings. We developed a nanosystem using HepG2 cancer cell membrane-cloaked zinc glutamate-modified Prussian blue nanoparticles with triphenylphosphine-conjugated lonidamine (HmPGTL NPs). This innovative approach achieved an efficient mild-temperature PTT effect by downregulating the production of intracellular ATP. This disrupts a section of heat shock proteins that cushion cancer cells against heat. The physicochemical properties, anti-tumor efficacy, and mechanisms of HmPGTL NPs both in vitro and in vivo were investigated. Moreover, the nanoparticles cloaked with the HepG2 cell membrane substantially prolonged the circulation time in vivo. Overall, the designed nanocomposites enhance the efficacy of mild-temperature PTT by disrupting the production of ATP in cancer cells. Thus, we anticipate that the mild-temperature PTT nanosystem will certainly present its enormous potential in various biomedical applications.
KW  - Prussian blue nanoparticles
KW  - lonidamine
KW  - mild-temperature photothermal therapy
KW  - heat shock proteins
KW  - cancer cell membrane
Y1  - 2021
SN  - 1944-8244
SS  - 1944-8244
U6  - https://doi.org/10.1021/acsami.1c11138
DO  - https://doi.org/10.1021/acsami.1c11138
VL  - 13
IS  - 31
SP  - 37563
EP  - 37577
S1  - 15
PB  - American Chemical Society
CY  - Washington, DC
ER  -