TY - JOUR U1 - Zeitschriftenartikel, wissenschaftlich - begutachtet (reviewed) A1 - Lehnert, Ralph A1 - Schilling, Richard T1 - Accuracy of molar solubility prediction from Hansen parameters : an exemplified treatment of the bioantioxidant l-ascorbic acid JF - Applied Sciences N2 - Estimating molar solubility from the Hildebrand-Scott relation employing Hansen solubility parameters (HSP) is widely presumed a valid semi quantitative approach. To test this presumption and to determine quantitatively the inherent accuracy of such a solubility prognosis, l-ascorbic acid (LAA) was treated as an example of a commercially important solute. Analytical calculus and Monte Carlo (MC) simulation were performed for 20 common solvents with total HSP ranging from 14.5 to 33.0 (MPa)0.5 utilizing validated material data. It was found that, due to the uncertainty of the material data used in the calculations, the solubility prediction had a large scattering and, thus, a low precision. KW - molar solubility estimation KW - ascorbic acid solubility KW - ascorbic acid Hansen parameter Y1 - 2020 UN - https://nbn-resolving.org/urn:nbn:de:bsz:rt2-opus4-27021 SN - 2076-3417 SS - 2076-3417 U6 - https://doi.org/10.3390/app10124266 DO - https://doi.org/10.3390/app10124266 VL - 10 IS - 12 SP - 1 EP - 11 S1 - 11 PB - MDPI CY - Basel ER -