TY  - JOUR
U1  - Zeitschriftenartikel, wissenschaftlich - begutachtet (reviewed)
A1  - Jung, Ole
A1  - Barbeck, Mike
A1  - Fan, Lu
A1  - Korte, Fabian
A1  - Zhao, Cuifeng
A1  - Krastev, Rumen
A1  - Pantermehl, Sven
A1  - Xiong, Xin
T1  - In vitro and ex vivo analysis of collagen foams for soft and hard tissue regeneration
JF  - In vivo : international journal of experimental and clinical pathophysiology and drug research
N2  - Background/Aim: The aim of this study was the conception, production, material analysis and cytocompatibility analysis of a new collagen foam for medical applications. Materials and Methods: After the innovative production of various collagen sponges from bovine sources, the foams were analyzed ex vivo in terms of their structure (including pore size) and in vitro in terms of cytocompatibility according to EN ISO 10993-5/-12. In vitro, the collagen foams were compared with the established soft and hard tissue materials cerabone and Jason membrane (both botiss biomaterials GmbH, Zossen, Germany). Results: Collagen foams with different compositions were successfully produced from bovine sources. Ex vivo, the foams showed a stable and long-lasting primary structure quality with a bubble area of 1,000 to 2,000 μm2. In vitro, all foams showed sufficient cytocompatibility. Conclusion: Collagen sponges represent a promising material for hard and soft tissue regeneration. Future studies could focus on integrating and investigating different additives in the foams.
KW  - collagen
KW  - collagen foam
KW  - tissue regeneration
KW  - macrophages
KW  - vascularization
KW  - soft tissue
KW  - hard tissue
Y1  - 2021
UN  - https://nbn-resolving.org/urn:nbn:de:bsz:rt2-opus4-35015
SN  - 1791-7549
SS  - 1791-7549
U6  - https://doi.org/10.21873/invivo.12536
DO  - https://doi.org/10.21873/invivo.12536
VL  - 35
IS  - 5
SP  - 2541
EP  - 2549
S1  - 9
PB  - IIAR
CY  - Kapandriti, Attiki
ER  -