TY  - JOUR
U1  - Zeitschriftenartikel, wissenschaftlich - begutachtet (reviewed)
A1  - Yamada, Yu‑ichi
A1  - Yamada, Gen
A1  - Otsuka, Mitsuo
A1  - Nishikiori, Hirotaka
A1  - Ikeda, Kimiyuki
A1  - Umeda, Yasuaki
A1  - Ohnishi, Hirofumi
A1  - Kuronuma, Koji
A1  - Chiba, Hirofumi
A1  - Baumbach, Jörg
A1  - Takahashi, Hiroki
T1  - Volatile organic compounds in exhaled breath of idiopathic pulmonary fibrosis for discrimination from healthy subjects
JF  - Lung
N2  - Purpose: Human breath analysis is proposed with increasing frequency as a useful tool in clinical application. We performed this study to find the characteristic volatile organic compounds (VOCs) in the exhaled breath of patients with idiopathic pulmonary fibrosis (IPF) for discrimination from healthy subjects. Methods: VOCs in the exhaled breath of 40 IPF patients and 55 healthy controls were measured using a multi-capillary column and ion mobility spectrometer. The patients were examined by pulmonary function tests, blood gas analysis, and serum biomarkers of interstitial pneumonia. Results: We detected 85 VOC peaks in the exhaled breath of IPF patients and controls. IPF patients showed 5 significant VOC peaks; p-cymene, acetoin, isoprene, ethylbenzene, and an unknown compound. The VOC peak of p-cymene was significantly lower (p < 0.001), while the VOC peaks of acetoin, isoprene, ethylbenzene, and the unknown compound were significantly higher (p < 0.001 for all) compared with the peaks of controls. Comparing VOC peaks with clinical parameters, negative correlations with VC (r =−0.393, p = 0.013), %VC (r =−0.569, p < 0.001), FVC (r = −0.440, p = 0.004), %FVC (r =−0.539, p < 0.001), DLco (r =−0.394, p = 0.018), and %DLco (r =−0.413, p = 0.008) and a positive correlation with KL-6 (r = 0.432, p = 0.005) were found for p-cymene. Conclusion: We found characteristic 5 VOCs in the exhaled breath of IPF patients. Among them, the VOC peaks of p-cymene were related to the clinical parameters of IPF. These VOCs may be useful biomarkers of IPF.
KW  - idiopathic pulmonary fibrosis
KW  - volatile organic compound
KW  - multi-capillary column
KW  - ion mobility spetrometer
KW  - exhaled breath
Y1  - 2017
SN  - 0341-2040
SS  - 0341-2040
U6  - https://doi.org/10.1007/s00408-017-9979-3
DO  - https://doi.org/10.1007/s00408-017-9979-3
VL  - 195
IS  - 2
SP  - 247
EP  - 254
S1  - 8
PB  - Springer
CY  - Berlin, Heidelberg
ER  -