TY  - JOUR
U1  - Zeitschriftenartikel, wissenschaftlich - begutachtet (reviewed)
A1  - Maurer, Felix
A1  - Lorenz, Dominik
A1  - Pielsticker, Gianluca
A1  - Volk, Thomas
A1  - Sessler, Daniel
A1  - Baumbach, Jörg
A1  - Kreuer, Sascha
T1  - Adherence of volatile propofol to various types of plastic tubing
JF  - Journal of breath research :  volatiles for medical diagnosis ; official journal of the International Association for Breath Research (IABR) and the International Society for Breath Odor Research (ISBOR)
N2  - Propofol is an intravenous anesthetic. Currently, it is not possible to routinely measure blood concentration of the drug in real time. However, multi-capillary column ion-mobility spectrometry of exhaled gas can estimate blood propofol concentration.Unfortunately, adhesion of volatile propofol on plastic materials complicates measurements. Therefore, it is necessary to consider the extent to which volatile propofol adheres to various plastics used in sampling tubing. Perfluoralkoxy (PFA), polytetrafluorethylene (PTFE), polyurethane (PUR), silicone, and Tygon tubing were investigated in an experimental setting using a calibration gas generator (HovaCAL). Propofol gas was measured for one hour at  26 °C, 50 °C, and 90 °C tubing temperature. Test tubing segments were then flushed with N2 to quantify desorption. PUR and Tygon sample tubing absorbed all volatile propofol. The silicone tubing reached the maximum propofol concentration after 119 min which was 29 min after  propofol gas exposure stopped. The use of PFAor PTFE tubing produced comparable and reasonably accurate propofol measurements. The desaturation time for the PFA  was 10 min shorter at 26 °C than for PTFE. PFA tubing thus seems most suitable for measurement of volatile propofol,with PTFE as an alternative.
KW  - breath analysis
KW  - drug monitoring
KW  - ion mobility spectrometry
KW  - propofol
Y1  - 2017
SN  - 1752-7163
SS  - 1752-7163
U6  - https://doi.org/10.1088/1752-7163/aa567e
DO  - https://doi.org/10.1088/1752-7163/aa567e
VL  - 11
IS  - 1
SP  - 1
EP  - 6
S1  - 6
PB  - IOP Publishing
CY  - Bristol
ER  -