TY  - JOUR
U1  - Zeitschriftenartikel, wissenschaftlich - begutachtet (reviewed)
A1  - Athanasopulu, Kiriaki
A1  - Kutuzova, Larysa
A1  - Thiel, Joana
A1  - Lorenz, Günter
A1  - Kemkemer, Ralf
T1  - Enhancing the biocompatibility of silicone-polycarbonate urethane based implant materials
JF  - Current directions in biomedical engineering
N2  - Polyurethane-bases block copolymers (TPCUs) are block-copolymers with systematically varied soft and hard segments. They have been suggested to serve as material for chondral implants in joint regeneration. Such applications may require the adhesion of chondrocytes to the implant surface, facilitating cell growth while keeping their phenotype. Thus, aims of this work were (1) to modify the surface of soft biostable polyurethane-based model implants (TPCU and TSiPCU) with high-molecular weight hyaluronic acid (HA) using an optimized multistep strategy of immobilization, and (2) to evaluate bioactivity of the modified TPCUs in vitro. Our results show no cytotoxic potential of the TPCUs. HAbioactive molecules (Mw =700kDa) were immobilized onto the polyurethane surface via polyethylenimine (PEI) spacers, and modifications were confirmed by several characterization methods. Tests with porcine chondrocytes indicated the potential of the TPCU-HA for inducing enhanced cell proliferation.
Y1  - 2019
UN  - https://nbn-resolving.org/urn:nbn:de:bsz:rt2-opus4-24493
SN  - 2364-5504
SS  - 2364-5504
U6  - https://doi.org/10.1515/cdbme-2019-0114
DO  - https://doi.org/10.1515/cdbme-2019-0114
VL  - 5
IS  - 1
SP  - 453
EP  - 456
S1  - 4
PB  - De Gruyter
CY  - Berlin
ER  -