TY - JOUR U1 - Zeitschriftenartikel, wissenschaftlich - begutachtet (reviewed) A1 - Yang, Linxiao A1 - Zhang, Zenghao A1 - Athanasopulu, Kiriaki A1 - Frey, Kerstin A1 - Cui, Zhishan A1 - Su, Haijia A1 - Luo, Liu A1 - Kemkemer, Ralf T1 - Surface modification of Polydimethylsiloxane by hydrogels for microfluidic applications JF - Current directions in biomedical engineering N2 - In vitro, hydrogel-based ECMs for functionalizing surfaces of various material have played an essential role in mimicking native tissue matrix. Polydimethylsiloxane (PDMS) is widely used to build microfluidic or organ-on-chip devices compatible with cells due to its easy handling in cast replication. Despite such advantages, the limitation of PDMS is its hydrophobic surface property. To improve wettability of PDMS-based devices, alginate, a naturally derived polysaccharide, was covalently bound to the PDMS surface. This alginate then crosslinked further hydrogel onto the PDMS surface in desired layer thickness. Hydrogel-modified PDMS was used for coating a topography chip system and in vitro investigation of cell growth on the surfaces. Moreover, such hydrophilic hydrogel-coated PDMS is utilized in a microfluidic device to prevent unspecific absorption of organic solutions. Hence, in both exemplary studies, PDMS surface properties were modified leading to improved devices. KW - PDMS KW - alginate KW - hydrogel KW - microfluidic chips KW - cell culture Y1 - 2019 UN - https://nbn-resolving.org/urn:nbn:de:bsz:rt2-opus4-23949 SN - 2364-5504 SS - 2364-5504 U6 - https://doi.org/10.1515/cdbme-2019-0024 DO - https://doi.org/10.1515/cdbme-2019-0024 VL - 5 IS - 1 SP - 93 EP - 96 S1 - 4 PB - De Gruyter CY - Berlin ER -