TY  - JOUR
A1  - Frey, Kerstin
A1  - Fischer, Alena
A1  - Krastev, Rumen
A1  - Kemkemer, Ralf
T1  - CurvChip - chip platform for investigating cell responses to curved surface features
T2  - Current directions in biomedical engineering
N2  - Surface topographies are often discussed as an important parameter influencing basic cell behavior. Whereas most in vitro studies deal with microstructures with sharp edges, smooth, curved microscale topographies might be more relevant concerning in-vivo situations. Addressing the lack of highly defined surfaces with varying curvature, we present a topography chip system with 3D curved features of varying spacing, curvature radii as well as varying overall dimensions of curved surfaces. The CurvChip is produced by low-cost photolithography with thermal reflow, subsequent (repetitive) PDMS molding and hot embossing. The platform facilitates the systematic in-vitro investigation of the impact of substrate curvature on cell types like epithelial, endothelial, smooth muscle cells, or stem cells. Such investigations will not only help to further understand the mechanism of curvature sensation but may also contribute to optimize cell-material interactions in the field of regenerative medicine.
KW  - photolithography
KW  - thermal reflow
KW  - topography with defined 3D curvature
KW  - chip platform
Y1  - 2018
UR  - https://publikationen.reutlingen-university.de/frontdoor/index/index/docId/2150
UR  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bsz:rt2-opus4-21505
SN  - 2364-5504
VL  - 4
IS  - 1
SP  - 453
EP  - 456
PB  - De Gruyter
CY  - Berlin
ER  -