TY  - JOUR
U1  - Zeitschriftenartikel, wissenschaftlich - begutachtet (reviewed)
A1  - Sun, Lili
A1  - Xiong, Xin
A1  - Zou, Qiaogen
A1  - Ouyang, Pingkai
A1  - Burkhardt, Claus
A1  - Krastev, Rumen
T1  - Design of intelligent chitosan/heparin hollow microcapsules for drug delivery
JF  - Journal of applied polymer science
N2  - In this study, a novel strategy has been developed for the assembly of polyelectrolyte multilayer (PEM) on CaCO3 templates in acidic pH solutions, where consecutive polyelectrolyte layers (heparin/poly(allylamine hydrochloride) or heparin/chitosan) were deposited on PEM hollow microcapsules established previously on CaCO3 templates. The PEM build-up, hollow capsule characterization and successful encapsulation of fluorescein 5(6)-isothiocyanate (FITC)-Dextran by coprecipitation with CaCO3 are demonstrated. Improvement by the removal of CaCO3 core was achieved while the depositions. In the course of the release profile, high retardation for encapsulated FITC-Dextran was observed. The combined shell capsules system is a significant trait that has potential use in tailoring functional layer-by-layer capsules as intelligent drug delivery vehicles where the preliminary in vitro tests showed the responsiveness on the enzymes.
KW  - biomedical applications
KW  - drug delivery systems
KW  - polyelectrolytes
Y1  - 2017
SN  - 0021-8995
SS  - 0021-8995
U6  - https://doi.org/10.1002/app.44425
DO  - https://doi.org/10.1002/app.44425
VL  - 134
IS  - 5
SP  - 1
EP  - 10
S1  - 10
PB  - Wiley
CY  - New York, NY
ER  -