TY - JOUR U1 - Zeitschriftenartikel, wissenschaftlich - begutachtet (reviewed) A1 - Greiner, Alexandra A1 - Sales, Adria A1 - Chen, Hao A1 - Biela, Sarah A1 - Kaufmann, Dieter A1 - Kemkemer, Ralf T1 - Nano- and microstructured materials for in vitro studies of the physiology of vascular cells JF - Beilstein journal of nanotechnology N2 - The extracellular environment of vascular cells in vivo is complex in its chemical composition, physical properties, and architecture. Consequently, it has been a great challenge to study vascular cell responses in vitro, either to understand their interaction with their native environment or to investigate their interaction with artificial structures such as implant surfaces. New procedures and techniques from materials science to fabricate bio-scaffolds and surfaces have enabled novel studies of vascular cell responses under well-defined, controllable culture conditions. These advancements are paving the way for a deeper understanding of vascular cell biology and materials–cell interaction. Here, we review previous work focusing on the interaction of vascular smooth muscle cells (SMCs) and endothelial cells (ECs) with materials having micro- and nanostructured surfaces. We summarize fabrication techniques for surface topographies, materials, geometries, biochemical functionalization, and mechanical properties of such materials. Furthermore, various studies on vascular cell behavior and their biological responses to micro- and nanostructured surfaces are reviewed. Emphasis is given to studies of cell morphology and motility, cell proliferation, the cytoskeleton and cell-matrix adhesions, and signal transduction pathways of vascular cells. We finalize with a short outlook on potential interesting future studies. KW - fabrication methods KW - materials selection KW - nano- and micro-topography KW - vascular endothelial cells KW - vascular smooth muscle cells Y1 - 2016 UN - https://nbn-resolving.org/urn:nbn:de:bsz:rt2-opus4-10710 SN - 2190-4286 SS - 2190-4286 U6 - https://doi.org/10.3762/bjnano.7.155 DO - https://doi.org/10.3762/bjnano.7.155 VL - 7 SP - 1620 EP - 1641 S1 - 22 PB - Beilstein-Institut zur Förderung der Chemischen Wissenschaften CY - Frankfurt am Main ER -