TY - JOUR U1 - Zeitschriftenartikel, wissenschaftlich - begutachtet (reviewed) A1 - Sales, Adria A1 - Wang, Fanlu A1 - Chen, Hao A1 - Kemkemer, Ralf A1 - Greiner, Alexandra T1 - Cell-age and cell type-dependent behavior of human vascular cells on micro-structured or soft polymer substrates JF - Biomedizinische Technik / Biomedical Engineering N2 - Increasing number of studies are focused on how adherent cells respond, in vitro, to different properties of a material. Typical properties are the surface chemistry, topographical cues (at the nano- and micro-scale) of the surface, and the substrate stiffness. Cell Response studies are of importance for designing new biomaterials with applications in cell culture technologies, regenerative medicine, or for medical implants. However, only very few studies take the cell age factor, respectively the donor age, into account. In this work, we tested two types of human vascular cells (smooth muscle and endothelial cells) from old and young donors on (a) micro-structured surfaces made of pol (dimethylsiloxane) or on (b) flat polyacrylamide hydrogels with varying stiffnesses. These experiments reveal age-dependent and cell typedependent differences in the cell response to the topography and stiffness, and may establish the Basis for further studies focusing on cell age-dependent responses. Y1 - 2014 UN - https://nbn-resolving.org/urn:nbn:de:bsz:rt2-opus4-801 SN - 1862-278X SS - 1862-278X U6 - https://doi.org/10.1515/bmt-2014-5003 DO - https://doi.org/10.1515/bmt-2014-5003 VL - 59 IS - s1 : Track D - Cellular, Tissue and Bioengineering SP - S286 EP - S289 S1 - 4 PB - de Gruyter CY - Berlin ER -