TY - JOUR U1 - Zeitschriftenartikel, wissenschaftlich - begutachtet (reviewed) A1 - Athanasopulu, Kiriaki A1 - Caltzidou, Dimitra A1 - Sekishita, Asuka A1 - Kutuzova, Larysa A1 - Lorenz, Günter A1 - Tanaka, Masaru A1 - Kemkemer, Ralf T1 - Sulfated hyaluronan coating of polyurethanebased implant materials JF - Current directions in biomedical engineering N2 - Thermoplastic polycarbonate urethane elastomers (TPCU) are potential implant materials for treating degenerative joint diseases thanks to their adjustable rubber-like properties, their toughness, and their durability. We developed a water-containing high-molecular-weight sulfated hyaluronic acid-coating to improve the interaction of TPCU with the synovial fluid. It is suggested that trapped synovial fluid can act as a lubricant that reduces the friction forces and thus provides an enhanced abrasion resistance of TPCU implants. Aims of this work were (i) the development of a coating method for novel soft TPCU with high-molecular sulfated hyaluronic acid to increase the biocompatibility and (ii) the in vitro validation of the functionalized TPCUs in cell culture experiments. KW - PURs KW - surface modification KW - sulfated hyaluronic acid KW - implant coating Y1 - 2020 UN - https://nbn-resolving.org/urn:nbn:de:bsz:rt2-opus4-30116 SN - 2364-5504 SS - 2364-5504 U6 - https://doi.org/10.1515/cdbme-2020-3115 DO - https://doi.org/10.1515/cdbme-2020-3115 VL - 6 IS - 3 SP - 1 EP - 4 S1 - 4 PB - De Gruyter CY - Berlin ER -