TY  - JOUR
U1  - Zeitschriftenartikel, wissenschaftlich - begutachtet (reviewed)
A1  - Kreuer, Sascha
A1  - Hauschild, Anne-Christin
A1  - Fink, Tobias
A1  - Baumbach, Jörg
A1  - Maddula, Sasidhar
A1  - Volk, Thomas
T1  - Two different approaches for pharmacokinetic modeling of exhaled drug concentrations
JF  - Scientific Reports
N2  - Online measurement of drug concentrations in patient's breath is a promising approach for individualized dosage. A direct transfer from breath- to blood-concentrations is not possible. Measured exhaled concentrations are following the blood-concentration with a delay in non-steady-state situations. Therefore, it is necessary to integrate the breath-concentration into a pharmacological model. Two different approaches for pharmacokinetic modelling are presented. Usually a 3-compartment model is used for pharmacokinetic calculations of blood concentrations. This 3-compartment model is extended with a 2-compartment model based on the first compartment of the 3-compartment model and a new lung compartment. The second approach is to calculate a time delay of changes in the concentration of the first compartment to describe the lung-concentration. Exemplarily both approaches are used for modelling of exhaled propofol. Based on time series of exhaled propofol measurements using an ion-mobility-spectrometer every minute for 346 min a correlation of calculated plasma and the breath concentration was used for modelling to deliver R2 = 0.99 interdependencies. Including the time delay modelling approach the new compartment coefficient ke0lung was calculated to ke0lung = 0.27 min−1 with R2 = 0.96. The described models are not limited to propofol. They could be used for any kind of drugs, which are measurable in patient's breath.
Y1  - 2014
UN  - https://nbn-resolving.org/urn:nbn:de:bsz:rt2-opus4-139
U6  - https://doi.org/10.1038/srep05423
DO  - https://doi.org/10.1038/srep05423
VL  - 4
SP  - 1
EP  - 6
S1  - 6
PB  - Springer
CY  - London
ER  -