TY - JOUR U1 - Zeitschriftenartikel, wissenschaftlich - begutachtet (reviewed) A1 - Barbeck, Mike A1 - Kühnel, Lennart A1 - Witte, Frank A1 - Pissarek, Jens A1 - Precht, Clarissa A1 - Xiong, Xin A1 - Krastev, Rumen A1 - Wegner, Nils A1 - Walther, Frank A1 - Jung, Ole T1 - Degradation, bone regeneration and tissue response of an innovative volume stable magnesium-supported GBR/GTR barrier membrane JF - International journal of molecular sciences N2 - Introduction: Bioresorbable collagenous barrier membranes are used to prevent premature soft tissue ingrowth and to allow bone regeneration. For volume stable indications, only non-absorbable synthetic materials are available. This study investigates a new bioresorbable hydrofluoric acid (HF)-treated magnesium (Mg) mesh in a native collagen membrane for volume stable situations. Materials and Methods: HF-treated and untreated Mg were compared in direct and indirect cytocompatibility assays. In vivo, 18 New Zealand White Rabbits received each four 8 mm calvarial defects and were divided into four groups: (a) HF-treated Mg mesh/collagen membrane, (b) untreated Mg mesh/collagen membrane (c) collagen membrane and (d) sham operation. After 6, 12 and 18 weeks, Mg degradation and bone regeneration was measured using radiological and histological methods. Results: In vitro, HF-treated Mg showed higher cytocompatibility. Histopathologically, HF-Mg prevented gas cavities and was degraded by mononuclear cells via phagocytosis up to 12 weeks. Untreated Mg showed partially significant more gas cavities and a fibrous tissue reaction. Bone regeneration was not significantly different between all groups. Discussion and Conclusions: HF-Mg meshes embedded in native collagen membranes represent a volume stable and biocompatible alternative to the non-absorbable synthetic materials. HF-Mg shows less corrosion and is degraded by phagocytosis. However, the application of membranes did not result in higher bone regeneration. KW - barrier membrane KW - GBR/GTR membrane KW - degradation KW - magnesium KW - collagen KW - in vivo KW - histomorphometry KW - tissue reaction Y1 - 2020 UN - https://nbn-resolving.org/urn:nbn:de:bsz:rt2-opus4-30199 SN - 1422-0067 SS - 1422-0067 U6 - https://doi.org/10.3390/ijms21093098 DO - https://doi.org/10.3390/ijms21093098 VL - 21 IS - 9 SP - 1 EP - 22 S1 - 22 PB - MDPI CY - Basel ER -