TY  - JOUR
U1  - Zeitschriftenartikel, wissenschaftlich - begutachtet (reviewed)
A1  - Tendulkar, Gauri
A1  - Sreekumar, Vrinda
A1  - Rupp, Frank
A1  - Teotia, Arun
A1  - Athanasopulu, Kiriaki
A1  - Kemkemer, Ralf
T1  - Characterisation of porous knitted titanium for replacement of intervertebral disc nucleus pulposus
JF  - Scientific reports
N2  - Effective restoration of human intervertebral disc degeneration is challenged by numerous limitations of the currently available spinal fusion and arthroplasty treatment strategies. Consequently, use of artificial biomaterial implant is gaining attention as a potential therapeutic strategy. Our study is aimed at investigating and characterizing a novel knitted titanium (Ti6Al4V) implant for the replacement of nucleus pulposus to treat early stages of chronic intervertebral disc degeneration. Specific knitted geometry of the scaffold with a porosity of 67.67 ± 0.824% was used to overcome tissue integration failures. Furthermore, to improve the wear resistance without impairing original mechanical strength, electro-polishing step was employed. Electro-polishing treatment changed a surface roughness from 15.22 ± 3.28 to 4.35 ± 0.87 μm without affecting its wettability which remained at 81.03 ± 8.5°. Subsequently, cellular responses of human mesenchymal stem cells (SCP1 cell line) and human primary chondrocytes were investigated which showed positive responses in terms of adherence and viability. Surface wettability was further enhanced to super hydrophilic nature by oxygen plasma treatment, which eventually caused substantial increase in the proliferation of SCP1 cells and primary chondrocytes. Our study implies that owing to scaffolds physicochemical and biocompatible properties, it could improve the clinical performance of nucleus pulposus replacement.
Y1  - 2017
UN  - https://nbn-resolving.org/urn:nbn:de:bsz:rt2-opus4-17520
SN  - 2045-2322
SS  - 2045-2322
U6  - https://doi.org/10.1038/s41598-017-16863-8
DO  - https://doi.org/10.1038/s41598-017-16863-8
VL  - 7
IS  - article nr. 16611
SP  - 1
EP  - 12
S1  - 12
PB  - Nature Publishing Group
CY  - London
ER  -