TY - JOUR U1 - Zeitschriftenartikel, wissenschaftlich - begutachtet (reviewed) A1 - Huber, Birgit A1 - Volz, Ann-Cathrin A1 - Kluger, Petra T1 - Understanding the effects of mature adipocytes and endothelial cells on fatty acid metabolism and vascular tone in physiological fatty tissue for vascularized adipose tissue engineering JF - Cell & tissue research N2 - Engineering of large vascularized adipose tissue constructs is still a challenge for the treatment of extensive high-graded burns or the replacement of tissue after tumor removal. Communication between mature adipocytes and endothelial cells is important for homeostasis and the maintenance of adipose tissue mass but, to date, is mainly neglected in tissue engineering strategies. Thus, new coculture strategies are needed to integrate adipocytes and endothelial cells successfully into a functional construct. This review focuses on the cross-talk of mature adipocytes and endothelial cells and considers their influence on fatty acid metabolism and vascular tone. In addition, the properties and challenges with regard to these two cell types for vascularized tissue engineering are highlighted. KW - mature adipocytes KW - endothelial cells KW - co-culture KW - vascularized fatty tissue engineering KW - cross-talk Y1 - 2015 SN - 0302-766X SS - 0302-766X U6 - https://doi.org/10.1007/s00441-015-2274-9 DO - https://doi.org/10.1007/s00441-015-2274-9 VL - 362 IS - 2 SP - 269 EP - 279 S1 - 11 PB - Springer CY - Berlin, Heidelberg ER -