TY  - JOUR
U1  - Zeitschriftenartikel, wissenschaftlich - begutachtet (reviewed)
A1  - Volz, Ann-Cathrin
A1  - Huber, Birgit
A1  - Kluger, Petra
T1  - Adipose-derived stem cell differentiation as a basic tool for vascularized adipose tissue engineering
JF  - Differentiation : the journal of the International Society of Differentiation
N2  - The development of in vitro adipose tissue constructs is highly desired to cope with the increased demand for substitutes to replace damaged soft tissue after high graded burns, deformities or tumor removal. To achieve clinically relevant dimensions, vascularization of soft tissue constructs becomes inevitable but still poses a challenge. Adipose-derived stem cells (ASCs) represent a promising cell source for the setup of vascularized fatty tissue constructs as they can be differentiated into adipocytes and endothelial cells in vitro and are thereby available in sufficiently high cell numbers.
This review summarizes the currently known characteristics of ASCs and achievements in adipogenic and endothelial differentiation in vitro. Further, the interdependency of adipogenesis and angiogenesis based on the crosstalk of endothelial cells, stem cells and adipocytes is addressed at the molecular level. Finally, achievements and limitations of current co-culture conditions for the construction of vascularized adipose tissue are evaluated.
KW  - adipose-derived stem cells
KW  - differentiation
KW  - endothelial cells
KW  - crosstalk
KW  - co-culture
KW  - vascularized adipose tissue engineering
Y1  - 2016
SN  - 0301-4681
SS  - 0301-4681
U6  - https://doi.org/10.1016/j.diff.2016.02.003
DO  - https://doi.org/10.1016/j.diff.2016.02.003
VL  - 92
IS  - 1-2
SP  - 52
EP  - 64
S1  - 13
PB  - Elsevier
CY  - New York, NY
ER  -