TY - JOUR U1 - Zeitschriftenartikel, wissenschaftlich - begutachtet (reviewed) A1 - Kapogianni, Eleni A1 - Barbeck, Mike A1 - Jung, Ole A1 - Arslan, Aylin A1 - Kuhnel, Lennart A1 - Xiong, Xin A1 - Krastev, Rumen T1 - Comparison of material-mediated bone regeneration capacities of sintered and non-sintered xenogeneic bone substitutes via 2D and 3D data JF - In vivo : international journal of experimental and clinical pathophysiology and drug research N2 - Background/Aim: The aim of this study was the development of a new osteoconductivity index to determine the bone healing capacities of bone substitute materials (BSM) on the basis of 3D microcomputed tomographic (μ-CT) data. Materials and Methods: Sinus biopsies were used for the comparative analysis of the integration behavior of two xenogeneic BSM (cerabone® and Bio Oss®). 3D μ-CT and data sets from histomorphometrical measurements based on 2D histological slices were used to measure the bone-material-contact and the tissue distribution within the biopsies. The tissue reactions to both BSM were microscopically analyzed. Results: The 3D and 2D results of the osteoconductivity measurements showed comparable material-bone contacts for both BSM, but the 2D data were significantly lower. The same results were found when tissue distribution was measured in both groups. The histopathological analysis showed comparative tissue reactions in both BSM. Conclusion: Osteoconductivity index is a reliable measurement parameter for determining the healing capacities of BSM. The observed differences between both measurement methods could be assigned to the resolution capacity of μ-CT data that did not allow for a precise interface distinction between both BSM and bone tissue. Histomorphometrical data based on histological slides still allow for a more exact evaluation. KW - osteoconductivity index KW - micro-CT KW - histomorphometry KW - xenogeneic bone substitute KW - tissue response KW - bone regeneration Y1 - 2019 UN - https://nbn-resolving.org/urn:nbn:de:bsz:rt2-opus4-25518 SN - 0258-851X SS - 0258-851X U6 - https://doi.org/10.21873/invivo.11719 DO - https://doi.org/10.21873/invivo.11719 VL - 33 IS - 6 SP - 2169 EP - 2179 S1 - 11 PB - IIAR CY - Kapandriti, Attiki ER -