TY  - JOUR
U1  - Zeitschriftenartikel, wissenschaftlich - begutachtet (reviewed)
A1  - Paradiso, Patrizia
A1  - Colaço, Rogério
A1  - Mata, José
A1  - Krastev, Rumen
A1  - Saramago, Benilde
A1  - Serro, Ana
T1  - Drug release from liposome coated hydrogels for soft contact lenses: the blinking and temperature effect
JF  - Journal of biomedical materials research. - Part B. Applied biomaterials
N2  - In this article, liposome-based coatings aiming to control drug release from therapeutic soft contact lenses (SCLs) materials are analyzed. A PHEMA based hydrogel material loaded with levofloxacin is used as model system for this research. The coatings are formed by polyelectrolyte layers containing liposomes of 1,2-dimyristoyl-sn-glycero-3- phosphocholine (DMPC) and DMPC1cholesterol (DMPC1 CHOL). The effect of friction and temperature on the drug release is investigated. The aim of the friction tests is to simulate the blinking of the eyelid in order to verify if the SCLs materials coated with liposomes are able to keep their properties, in particular the drug release ability. It was observed that under the study conditions, friction did not affect significantly the drug release from the liposome coated PHEMA material. In contrast, increasing the temperature of release leads to an increase of the drug diffusion rate through the hydrogel. This phenomenon is recorded both in the control and in the coated samples.
KW  - soft contact lenses
KW  - liposomes
KW  - drug release
KW  - eyelid
KW  - friction
Y1  - 2017
SN  - 1552-4973
SS  - 1552-4973
U6  - https://doi.org/10.1002/jbm.b.33715
DO  - https://doi.org/10.1002/jbm.b.33715
VL  - 105
IS  - 7
SP  - 1799
EP  - 1807
S1  - 9
PB  - Wiley
CY  - Hoboken, NJ
ER  -