TY  - JOUR
U1  - Zeitschriftenartikel, wissenschaftlich - begutachtet (reviewed)
A1  - Kutuzova, Larysa
A1  - Molentor, Olga
A1  - Wu, Feng
A1  - Song, Wenyao
A1  - Kandelbauer, Andreas
A1  - Lorenz, Günter
T1  - Protective role of vitamin E to reduce oxidative degradation of soft implantable polyurethanes: in vitro study : from mechanical viewpoint
JF  - Current directions in biomedical engineering
N2  - Vitamin E (VitE) additives are important in treating osteoarthritis inclusive cartilage regeneration due to their antioxidant and anti-inflammatory properties. The present research study focuses on the ability of biological antioxidant VitE (alpha-tocopherol isoform) to reduce or minimize oxidative degradation of soft implantable polyurethane (PU) elastomers after extended periods of time (5 months) in vitro. The effect of the oxidation storage media on the morphology of the segmented PUs was evaluated by mechanical softening, crystallization and melting behavior of both soft and hard segments (SS, HS) using dynamic mechanical analysis (DMA). Bulk mechanical properties of the potential implant materials during ageing were predicted from comprehensive mechanical testing of the biomaterials under tension and compression cyclic loads. 5-months in vitro data suggest that the prepared siloxane-poly(carbonate urethane) formulations have sufficient resistance against degradation to be suitable materials for chondral long term bio-stable implants. Most importantly, the positive effect of incorporating VitE (0.5 or 1.0% w/w) as bio-antioxidant and lubricant on the bio-stability was observed for all PU types. VitE-additives protected the surface layer from erosion and cracking during chemical oxidation in vitro as well as from thermal oxidation during extrusion re-processing.
KW  - long-term implants
KW  - soft medical-grade polyurethanes
KW  - bio-antioxidant
KW  - in vitro test
Y1  - 2019
UN  - https://nbn-resolving.org/urn:nbn:de:bsz:rt2-opus4-25000
SN  - 2364-5504
SS  - 2364-5504
U6  - https://doi.org/10.1515/cdbme-2019-0113
DO  - https://doi.org/10.1515/cdbme-2019-0113
VL  - 5
IS  - 1
SP  - 449
EP  - 452
S1  - 4
PB  - De Gruyter
CY  - Berlin
ER  -