TY  - JOUR
U1  - Zeitschriftenartikel, wissenschaftlich - begutachtet (reviewed)
A1  - Doumanov, Jordan
A1  - Mladenova, Kirilka
A1  - Moskova-Doumanova, Vesselina
A1  - Andreeva, Tonya
A1  - Petrova, Svetla
T1  - Self-organization and surface properties of hBest1 in models of biological membranes
JF  - Advances in colloid and interface science
N2  - The transmembrane Ca2+ − activated Cl− channel - human bestrophin-1 (hBest1) is expressed in retinal pigment epithelium and mutations of BEST1 gene cause ocular degenerative diseases colectivelly referred to as “bestrophinopathies”. A large number of genetical, biochemical, biophysical and molecular biological studies have been performed to understand the relationship between structure and function of the hBest1 protein and its pathophysiological significance. Here, we review the current understanding of hBest1 surface organization, interactions with membrane lipids in model membranes, and its association with microdomains of cellular membranes. These highlights are significant for modulation of channel activity in cells.
KW  - hBest1
KW  - POPC
KW  - sphingomielin
KW  - surface films
KW  - lipid rafts
Y1  - 2022
SN  - 0001-8686
SS  - 0001-8686
U6  - https://doi.org/10.1016/j.cis.2022.102619
DO  - https://doi.org/10.1016/j.cis.2022.102619
VL  - 302
PB  - Elsevier
CY  - New York
ER  -