TY  - JOUR
U1  - Zeitschriftenartikel, wissenschaftlich - begutachtet (reviewed)
A1  - Brecht, Marc
A1  - Al Ktash, Mohammad
A1  - Stefanakis, Mona
A1  - Ostertag, Edwin
A1  - Boldrini, Barbara
ED  - Graña, Manuel
T1  - Characterization of pharmaceutical tablets using UV hyperspectral imaging as a rapid in-line analysis tool
JF  - Sensors
N2  - A laboratory prototype for hyperspectral imaging in ultra-violet (UV) region from 225 to 400 nm was developed and used to rapidly characterize active pharmaceutical ingredients (API) in tablets. The APIs are ibuprofen (IBU), acetylsalicylic acid (ASA) and paracetamol (PAR). Two sample sets were used for a comparison purpose. Sample set one comprises tablets of 100% API and sample set two consists of commercially available painkiller tablets. Reference measurements were performed on the pure APIs in liquid solutions (transmission) and in solid phase (reflection) using a commercial UV spectrometer. The spectroscopic part of the prototype is based on a pushbroom imager that contains a spectrograph and charge-coupled device (CCD) camera. The tablets were scanned on a conveyor belt that is positioned inside a tunnel made of polytetrafluoroethylene (PTFE) in order to increase the homogeneity of illumination at the sample position. Principal component analysis (PCA) was used to differentiate the hyperspectral data of the drug samples. The first two PCs are sufficient to completely separate all samples. The rugged design of the prototype opens new possibilities for further development of this technique towards real large-scale application.
KW  - hyperspectral imaging
KW  - pushbroom
KW  - UV spectroscopy
KW  - principle component analysis
KW  - active pharmaceutical ingredient API
KW  - process analytical technology PAT
Y1  - 2021
UN  - https://nbn-resolving.org/urn:nbn:de:bsz:rt2-opus4-32953
SN  - 1424-8220
SS  - 1424-8220
U6  - https://doi.org/10.3390/s21134436
DO  - https://doi.org/10.3390/s21134436
VL  - 21
SP  - 13
S1  - 13
PB  - MDPI
CY  - Basel
ER  -