TY  - JOUR
U1  - Zeitschriftenartikel, wissenschaftlich - begutachtet (reviewed)
A1  - Steinbach, Julia
A1  - Fait, Fabio
A1  - Wagner, Stefanie
A1  - Wagner, Alexandra
A1  - Brecht, Marc
A1  - Mayer, Hermann
A1  - Kandelbauer, Andreas
T1  - Rational design of pore parameters in monodisperse porous poly(glycidyl methacrylate-co-ethylene glycol dimethacrylate) particles based on response surface methodology
JF  - Polymers
N2  - Monodisperse porous poly(glycidyl methacrylate-co-ethylene glycol dimethacrylate) particles are widely applied in different fields, as their pore properties can be influenced and functionalization of the epoxy group is versatile. However, the adjustment of parameters which control morphology and pore properties such as pore volume, pore size and specific surface area is scarcely available. In this work, the effects of the process factors monomer:porogen ratio, GMA:EDMA ratio and composition of the porogen mixture on the response variables pore volume, pore size and specific surface area are investigated using a face centered central composite design. Non-linear effects of the process factors and second order interaction effects between them were identified. Despite the complex interplay of the process factors, targeted control of the pore properties was possible. For each response a response surface model was derived with high predictive power (all R2 predicted > 0.85). All models were tested by four external validation experiments and their validity and predictive power was demonstrated.
KW  - porous microspheres
KW  - design of experiment
KW  - seed swelling polymerization
KW  - p(GMA-co-EDMA)
KW  - particles
KW  - monodisperse
KW  - pores
KW  - morphology
KW  - process optimization
Y1  - 2022
UN  - https://nbn-resolving.org/urn:nbn:de:bsz:rt2-opus4-36334
SN  - 2073-4360
SS  - 2073-4360
U6  - https://doi.org/10.3390/polym14030382
DO  - https://doi.org/10.3390/polym14030382
VL  - 14
IS  - 3
SP  - 18
S1  - 18
PB  - MDPI
CY  - Basel
ER  -