Regulation of the growth, morphology, mechanical properties and biocompatibility of natural polysaccharide-based multilayers by Hofmeister anions
- Herein the optimization of the physicochemical properties and surface biocompatibility of polyelectrolyte multilayers of the natural, biocompatible and biodegradable, linear polysaccharides hyaluronan and chitosan by Hofmeister anions was systematically investigated. We demonstrated that there is an interconnection between the bulk and surface properties of HA/Chi multilayers both varying in accordance with the arrangement of the anions in the Hofmeister series. Kosmotropic anions increased the hydration, thickness, micro- and macro-roughness, and hydrophilicity and improved the biocompatibility of the films by reduction (2 orders of magnitude) of the films stiffness and complete anti-thrombogenicity.
| Author of HS Reutlingen | Krastev, Rumen |
|---|---|
| DOI: | https://doi.org/10.1039/C6TB01638C |
| ISSN: | 1552-4973 |
| eISSN: | 1552-4981 |
| Erschienen in: | Journal of materials chemistry. - B. Materials for biology and medicine |
| Publisher: | The Royal Society of Chemistry |
| Place of publication: | Cambridge |
| Document Type: | Journal article |
| Language: | English |
| Publication year: | 2016 |
| Volume: | 4 |
| Issue: | 44 |
| Page Number: | 9 |
| First Page: | 7092 |
| Last Page: | 7100 |
| DDC classes: | 540 Chemie |
| Open access?: | Nein |
