Functionalization of PU-based materials for orthopedic applications
- Knee osteoarthritis is a common complication and can lead to total loss of joint function in patients. Treatment by either partial or total knee replacement with appropriate UHMWPE based implantsis highly invasive, may cause complications and may show unsatisfying results. Alternatively, treatment may be done by insertion of an elastic interpositional knee spacer with optimized material characteristics. We report the development of high performance polyurethane-based polymers modified with bioactive molecules for fabrication of such knee spacers. In order to tailor mechanical and tribological properties and to improve resist to enzymatic degradation we propose a core-shell model for the spacer with specifically adapted properties.
| Author of HS Reutlingen | Athanasopulu, Kiriaki; Kemkemer, Ralf; Lorenz, Günter; Kutuzova, Larysa |
|---|---|
| URN: | urn:nbn:de:bsz:rt2-opus4-13332 |
| DOI: | https://doi.org/10.1515/bnm-2016-1001 |
| ISSN: | 2193-066X |
| eISSN: | 2193-0651 |
| Erschienen in: | Bionanomaterials : journal of functional materials, biomechanics, and tissue engineering |
| Publisher: | De Gruyter |
| Place of publication: | Berlin |
| Document Type: | Journal article |
| Language: | English |
| Publication year: | 2016 |
| Volume: | 17 |
| Issue: | S1 |
| Page Number: | 1 |
| First Page: | 158 |
| DDC classes: | 610 Medizin, Gesundheit |
| Open access?: | Ja |
| Licence (German): |  Open Access |
