Inversely 3D-printed β-TCP scaffolds for bone replacement
- The aim of this study was to predefine the pore structure of β-tricalcium phosphate (β-TCP) scaffolds with different macro pore sizes (500, 750, and 1000 µm), to characterize β-TCP scaffolds, and to investigate the growth behavior of cells within these scaffolds. The lead structures for directional bone growth (sacrificial structures) were produced from polylactide (PLA) using the fused deposition modeling techniques. The molds were then filled with β-TCP slurry and sintered at 1250° C, whereby the lead structures (voids) were burnt out. The scaffolds were mechanically characterized (native and after incubation in simulated body fluid (SBF) for 28 d). In addition, biocompatibility was investigated by live/dead, cell proliferation and lactate dehydrogenase assays.
Author of HS Reutlingen | Lange, Svenja; Krastev, Rumen |
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URN: | urn:nbn:de:bsz:rt2-opus4-25486 |
DOI: | https://doi.org/10.3390/ma12203417 |
ISSN: | 1996-1944 |
Erschienen in: | Materials |
Publisher: | MDPI |
Place of publication: | Basel |
Document Type: | Journal article |
Language: | English |
Publication year: | 2019 |
Tag: | FDM; bone replacement; inversely; β-TCP |
Volume: | 12 |
Issue: | 20 |
Page Number: | 17 |
First Page: | 1 |
Last Page: | 17 |
Article Number: | 3417 |
DDC classes: | 600 Technik, Medizin, angewandte Wissenschaften |
Open access?: | Ja |
Licence (German): | Creative Commons - CC BY - Namensnennung 4.0 International |