Sulfated hyaluronan coating of polyurethanebased implant materials
- Thermoplastic polycarbonate urethane elastomers (TPCU) are potential implant materials for treating degenerative joint diseases thanks to their adjustable rubber-like properties, their toughness, and their durability. We developed a water-containing high-molecular-weight sulfated hyaluronic acid-coating to improve the interaction of TPCU with the synovial fluid. It is suggested that trapped synovial fluid can act as a lubricant that reduces the friction forces and thus provides an enhanced abrasion resistance of TPCU implants. Aims of this work were (i) the development of a coating method for novel soft TPCU with high-molecular sulfated hyaluronic acid to increase the biocompatibility and (ii) the in vitro validation of the functionalized TPCUs in cell culture experiments.
| Author of HS Reutlingen | Athanasopulu, Kiriaki; Caltzidou, Dimitra; Kutuzova, Larysa; Lorenz, Günter; Kemkemer, Ralf |
|---|---|
| URN: | urn:nbn:de:bsz:rt2-opus4-30116 |
| DOI: | https://doi.org/10.1515/cdbme-2020-3115 |
| ISSN: | 2364-5504 |
| Erschienen in: | Current directions in biomedical engineering |
| Publisher: | De Gruyter |
| Place of publication: | Berlin |
| Document Type: | Journal article |
| Language: | English |
| Publication year: | 2020 |
| Tag: | PURs; implant coating; sulfated hyaluronic acid; surface modification |
| Volume: | 6 |
| Issue: | 3 |
| Page Number: | 4 |
| First Page: | 1 |
| Last Page: | 4 |
| Article Number: | 20203115 |
| DDC classes: | 570 Biowissenschaften, Biologie |
| Open access?: | Ja |
| Licence (German): |  Creative Commons - CC BY - Namensnennung 4.0 International |
