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Functionalization of aminoalkylsilane-grafted bacterial nanocellulose with ZnO-NPs-doped pullulan electrospun nanofibers for multifunctional wound dressing

  • High moisture permeability, excellent mechanical properties in a wet state, high water-holding capability, and high exudate absorption make bacterial nanocellulose (BNC) a favorable candidate for biomedical device production, especially wound dressings. The lack of antibacterial activity and healing-promoting ability are the main drawbacks that limit its wide application. Pullulan (Pul) is a nontoxic polymer that can promote wound healing. Zinc oxide nanoparticles (ZnO-NPs) are well-known as a safe antibacterial agent. In this study, aminoalkylsilane was chemically grafted on a BNC membrane (A-g-BNC) and used as a bridge to combine BNC with Pul-ZnO-NPs hybrid electrospun nanofibers. FTIR results confirmed the successful production of A-g-BNC/Pul-ZnO. The obtained dressing demonstrated blood clotting performance better than that of BNC. The dressing showed an ability to release ZnO, and its antibacterial activity was up to 5 log values higher than that of BNC. The cytotoxicity of the dressing toward L929 fibroblast cells clearly showed safety due to the proliferation of fibroblast cells. The animal test in a rat model indicated faster healing and re-epithelialization, small blood vessel formation, and collagen synthesis in the wounds covered by A-g-BNC/Pul-ZnO. The new functional dressing, fabricated with a cost-effective and easy method, not only showed excellent antibacterial activity but could also accelerate wound healing.

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Metadaten
Author of HS ReutlingenAndreeva, Tonya; Krastev, Rumen
DOI:https://doi.org/10.1021/acsbiomaterials.1c00444
ISSN:2373-9878
Erschienen in:ACS biomaterials science & engineering
Publisher:ACS Publ.
Place of publication:Washington, DC
Document Type:Article
Language:English
Year of Publication:2021
Tag:anatomy; antibacterial activity; bacteria; materials; nanofibers
Volume:7
Issue:8
Page Number:14
First Page:3933
Last Page:3946
DDC classes:540 Chemie
Open Access?:Nein
Licence (English):License Logo  Lizenzbedingungen ACS