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Rational design of pore parameters in monodisperse porous poly(glycidyl methacrylate-co-ethylene glycol dimethacrylate) particles based on response surface methodology

  • Monodisperse porous poly(glycidyl methacrylate-co–ethylene glycol dimethacrylate) particles are widely applied in different fields, as their pore properties can be influenced and functionalization of the epoxy group is versatile. However, the adjustment of parameters which control morphology and pore properties such as pore volume, pore size and specific surface area is scarcely available. In this work, the effects of the process factors monomer:porogen ratio, GMA:EDMA ratio and composition of the porogen mixture on the response variables pore volume, pore size and specific surface area are investigated using a face centered central composite design. Non-linear effects of the process factors and second order interaction effects between them were identified. Despite the complex interplay of the process factors, targeted control of the pore properties was possible. For each response a response surface model was derived with high predictive power (all R2 predicted > 0.85). All models were tested by four external validation experiments and their validity and predictive power was demonstrated.

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Metadaten
Author of HS ReutlingenSteinbach, Julia; Fait, Fabio; Wagner, Alexandra; Brecht, Marc; Kandelbauer, Andreas
URN:urn:nbn:de:bsz:rt2-opus4-36334
DOI:https://doi.org/10.3390/polym14030382
ISSN:2073-4360
Erschienen in:Polymers
Publisher:MDPI
Place of publication:Basel
Document Type:Article
Language:English
Year of Publication:2022
Tag:design of experiment; monodisperse; morphology; p(GMA-co-EDMA); particles; pores; porous microspheres; process optimization; seed swelling polymerization
Volume:14
Issue:3
Page Number:18
Article Number:382
DDC classes:540 Chemie
Open Access?:Ja
Licence (German):License Logo  Creative Commons - CC BY - Namensnennung 4.0 International