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How mechanical and physicochemical material characteristics influence adipose-derived stem cell fate

  • Adipose-derived stem cells (ASCs) are a subpopulation of mesenchymal stem cells. Compared to bone marrow-derived stem cells, they can be harvested with minimal invasiveness. ASCs can be easily expanded and were shown to be able to differentiate into several clinically relevant cell types. Therefore, this cell type represents a promising component in various tissue engineering and medical approaches (e.g., cell therapy). In vivo cells are surrounded by the extracellular matrix (ECM) that provides a wide range of tissue-specific physical and chemical cues, such as stiffness, topography, and chemical composition. Cells can sense the characteristics of their ECM and respond to them in a specific cellular behavior (e.g., proliferation or differentiation). Thus, in vitro biomaterial properties represent an important tool to control ASCs behavior. In this review, we give an overview of the current research in the mechanosensing of ASCs and current studies investigating the impact of material stiffens, topography, and chemical modification on ASC behavior. Additionally, we outline the use of natural ECM as a biomaterial and its interaction with ASCs regarding cellular behavior.

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Metadaten
Author of HS ReutlingenNellinger, Svenja; Kluger, Petra
URN:urn:nbn:de:bsz:rt2-opus4-41064
DOI:https://doi.org/10.3390/ijms24043551
ISSN:1422-0067
Erschienen in:International journal of molecular sciences
Publisher:MDPI
Place of publication:Basel
Document Type:Journal article
Language:English
Publication year:2023
Tag:adipose-derived stem cells; biomaterials; modification; stiffness; topography
Volume:24
Issue:4
Page Number:26
First Page:1
Last Page:26
Article Number:3551
DDC classes:570 Biowissenschaften, Biologie
Open access?:Ja
Licence (German):License Logo  Creative Commons - CC BY - Namensnennung 4.0 International