Understanding the effects of mature adipocytes and endothelial cells on fatty acid metabolism and vascular tone in physiological fatty tissue for vascularized adipose tissue engineering
- Engineering of large vascularized adipose tissue constructs is still a challenge for the treatment of extensive high-graded burns or the replacement of tissue after tumor removal. Communication between mature adipocytes and endothelial cells is important for homeostasis and the maintenance of adipose tissue mass but, to date, is mainly neglected in tissue engineering strategies. Thus, new coculture strategies are needed to integrate adipocytes and endothelial cells successfully into a functional construct. This review focuses on the cross-talk of mature adipocytes and endothelial cells and considers their influence on fatty acid metabolism and vascular tone. In addition, the properties and challenges with regard to these two cell types for vascularized tissue engineering are highlighted.
| Author of HS Reutlingen | Kluger, Petra; Volz, Ann-Cathrin |
|---|---|
| DOI: | https://doi.org/10.1007/s00441-015-2274-9 |
| ISSN: | 0302-766X |
| eISSN: | 1432-0878 |
| Erschienen in: | Cell & tissue research |
| Publisher: | Springer |
| Place of publication: | Berlin, Heidelberg |
| Document Type: | Journal article |
| Language: | English |
| Publication year: | 2015 |
| Tag: | co-culture; cross-talk; endothelial cells; mature adipocytes; vascularized fatty tissue engineering |
| Volume: | 362 |
| Issue: | 2 |
| Page Number: | 11 |
| First Page: | 269 |
| Last Page: | 279 |
| DDC classes: | 570 Biowissenschaften, Biologie |
| Open access?: | Nein |
| Licence (German): |  In Copyright - Urheberrechtlich geschützt |
