Open Access

Mischa Uebachs, Philipp Wegner, Sebastian Schaaf, Simon Kugai, Heike Jacobi, Sheng-Han Kuo, Tetsuo Ashizawa, Juliane Fluck, Sophie Tezenas du Montcel, Peter Bauer, Paola Giunti, Arron Cook, Robyn Labrum, Michael H. Parkinson, Alexandra Durr, Alexis Brice, Perrine Charles, Cecilia Marelli, Caterina Mariotti, Lorenzo Nanetti, Marta Panzeri, Maria Rakowicz, Anna Sulek, Anna Sobanska, Tanja Schmitz-Hübsch, Ludger Schöls, Holger Hengel, Laszlo Baliko, Bela Melegh, Alessandro Filla, Antonella Antenora, Jon Infante, José Berciano, Bart P. van de Warrenburg, Dagmar Timmann, Sandra Szymanski, Sylvia Boesch, Jun-Suk Kang, Massimo Pandolfo, Jörg B. Schulz, Sonia Molho, Alhassane Diallo, Thomas Klockgether, Marcus Grobe-Einsler, Demet Önder, Mafalda Raposo, João Vasconcelos, Manuela Lima, Luís Pereira de Almeida, Patrick Silva, Jeannette Hübener-Schmid, Jennifer Faber, Inês Cunha, Hector Garcia-Moreno, Katarina Manso, Matthis Synofzik, Andreas Traschütz, Judith van Gaalen, Tessa Perbolt, Khalash Bushara, Diane Hutter, Leire Manrique, Andreas Thieme, Friedrich Erdlenbruch, Chiadi Onyike, Ann Fishman, Kathrin Reetz, Imis Dogan, Eva Ratai, Jeremy Schmahmann, Magda Santana, Karla P. Figueroa, Susan L. Perlman, Christopher M. Gomez, George R. Wilmot, Sarah H. Ying, Theresa A. Zesiewicz, Henry L. Paulson, Vikram G. Shakkottai, Michael D. Geschwind, Guangbin Xia, Stefan M. Pulst, Sub H. Subramnoy, Sandro Romanzetti, Florian Harmuth, Grzegorz Makowicz, Alessandro Roca, Carlo Casalo, Marcella Masciullo, Wolfgang Nachbauer, Katrin Bürk-Gergs, Olaf Riess, Berkan Koyak

• With SCAview, we present a prompt and comprehensive tool that enables scientists to browse large datasets of the most common spinocerebellar ataxias intuitively and without technical effort. Basic concept is a visualization of data, with a graphical handling and filtering to select and define subgroups and their comparison. Several plot types to visualize all data points resulting from the selected attributes are provided. The underlying synthetic cohort is based on clinical data from five different European and US longitudinal multicenter cohorts in spinocerebellar ataxia type 1, 2, 3, and 6 (SCA1, 2, 3, and 6) comprising > 1400 patients with overall > 5500 visits. First, we developed a common data model to integrate the clinical, demographic, and characterizing data of each source cohort. Second, the available datasets from each cohort were mapped onto the data model. Third, we created a synthetic cohort based on the cleaned dataset. With SCAview, we demonstrate the feasibility of mapping cohort data from different sources onto a common data model. The resulting browser-based visualization tool with a thoroughly graphical handling of the data offers researchers the unique possibility to visualize relationships and distributions of clinical data, to define subgroups and to further investigate them without any technical effort. Access to SCAview can be requested via the Ataxia Global Initiative and is free of charge.