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Hypericin: single molecule spectroscopy of an active natural drug

  • Hypericin is one of the most efficient photosensitizers used in photodynamic tumor therapy (PDT). The reported treatments of this drug reach from antidepressive, antineoplastic, antitumor and antiviral activity. We show that hypericin can be optically detected down to a single molecule at ambient conditions. Hypericin can even be observed inside of a cancer cell, which implies that this drug can be directly used for advanced microscopy techniques (PALM, spt-PALM, or FLIM). Its photostability is large enough to obtain single molecule fluorescence, surface enhanced Raman spectra (SERS), fluorescence lifetime, antibunching, and blinking dynamics. Sudden spectral changes can be associated with a reorientation of the molecule on the particle surface. These properties of hypericin are very sensitive to the local environment. Comparison of DFT calculations with SERS spectra show that both the neutral and deprotonated form of hypericin can be observed on the single molecule and ensemble level.

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Metadaten
Name:Hauler, Otto; Scholz, Miriam; Brecht, Marc
DOI:https://doi.org/10.1021/acs.jpca.9b11532
ISSN:1089-5639
eISSN:1520-5215
Erschienen in:The journal of physical chemistry. A. Molecules, spectroscopy, kinetics, environment & general theory
Publisher:American Chemical Society
Place of publication:Washington, DC
Document Type:Article
Language:English
Year of Publication:2020
Volume:124
Issue:12
Pagenumber:8
First Page:2497
Last Page:2504
Dewey Decimal Classification:540 Chemie
Open Access:Nein