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Exogenous factors of influence on exhaled breath analysis by ion-mobility spectrometry (MCC/IMS)

  • The interpretation of exhaled breath analysis needs to address to the influence of exogenous factors, especially to a transfer of confounding analytes by the test persons. A test person who was exposed to a disinfectant had exhaled breath analysis by MCC/IMS (Bioscout®) after different time intervals. Additionally, a new sampling method with inhalation of synthetic air before breath analysis was tested. After exposure to the disinfectant, 3-Pentanone monomer, 3-Pentanone dimer, Hexanal, 3-Pentanone trimer, 2-Propanamine, 1-Propanol, Benzene, Nonanal showed significantly higher intensities, in exhaled breath and air of the examination room, compared to the corresponding baseline measurements. Only one ingredient of the disinfectant (1-Propanol) was identical to the 8 analytes. Prolonging the time intervals between exposure and breath analysis showed a decrease of their intensities. However, the half-time of the decrease was different. The inhalation of synthetic air - more than consequently airing the examination room with fresh air - reduced the exogenous and also relevant endogenous analytes, leading to a reduction and even changing polarity of the alveolar gradient. The interpretation of exhaled breath needs further knowledge about the former residence of the proband and the likelihood and relevance of the inhalation of local, site-specific and confounding exogenous analytes by him. Their inhalation facilitates a transfer to the examination room and a detection of high concentrations in room air and exhaled breath, but also the exhalation of new analytes. This may lead to a misinterpretation of these analytes as endogenous resp. disease-specific ones.

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Metadaten
Name:Baumbach, Jörg Ingo
DOI:https://doi.org/10.1007/s12127-019-00247-x
ISSN:1865-4584
Erschienen in:International journal for ion mobility spectrometry : official publication of the International Society for Ion Mobility Spectrometry
Publisher:Springer
Place of publication:Berlin
Document Type:Article
Language:English
Year of Publication:2019
Tag:disinfectant; exhaled breath analysis; exogenous analytes; ion mobility spectrometry; multicapillary column
Volume:22
Issue:2
Pagenumber:11
First Page:59
Last Page:69
Dewey Decimal Classification:530 Physik
Open Access:Nein
Licence (German):License Logo  Lizenzbedingungen Springer