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A detailed comparison of analysis processes for MCC-IMS data in disease classification - automated methods can replace manual peak annotations

  • The best fully automated analysis process achieves even better classification results than the established manual process. The best algorithms for the three analysis steps are (i) SGLTR (Savitzky-Golay Laplace operator filter thresholding regions) and LM (Local Maxima) for automated peak identification, (ii) EM clustering (Expectation Maximization) and DBSCAN (Density-Based Spatial Clustering of Applications with Noise) for the clustering step and (iii) RF (Random Forest) for multivariate classification. Thus, automated methods can replace the manual steps in the analysis process to enable an unbiased high throughput use of the technology.

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Metadaten
Author of HS ReutlingenBaumbach, Jörg Ingo
URN:urn:nbn:de:bsz:rt2-opus4-14870
DOI:https://doi.org/10.1371/journal.pone.0184321
eISSN:1932-6203
Erschienen in:PLOS ONE
Publisher:PLOS
Place of publication:Lawrence, Kan.
Document Type:Journal article
Language:English
Publication year:2017
Volume:12
Issue:9
Page Number:16
First Page:1
Last Page:16
DDC classes:610 Medizin, Gesundheit
Open access?:Ja
Licence (German):License Logo  Creative Commons - Namensnennung