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Volatile organic compounds in exhaled breath of idiopathic pulmonary fibrosis for discrimination from healthy subjects

  • Purpose: Human breath analysis is proposed with increasing frequency as a useful tool in clinical application. We performed this study to find the characteristic volatile organic compounds (VOCs) in the exhaled breath of patients with idiopathic pulmonary fibrosis (IPF) for discrimination from healthy subjects. Methods: VOCs in the exhaled breath of 40 IPF patients and 55 healthy controls were measured using a multi-capillary column and ion mobility spectrometer. The patients were examined by pulmonary function tests, blood gas analysis, and serum biomarkers of interstitial pneumonia. Results: We detected 85 VOC peaks in the exhaled breath of IPF patients and controls. IPF patients showed 5 significant VOC peaks; p-cymene, acetoin, isoprene, ethylbenzene, and an unknown compound. The VOC peak of p-cymene was significantly lower (p < 0.001), while the VOC peaks of acetoin, isoprene, ethylbenzene, and the unknown compound were significantly higher (p < 0.001 for all) compared with the peaks of controls. Comparing VOC peaks with clinical parameters, negative correlations with VC (r =−0.393, p = 0.013), %VC (r =−0.569, p < 0.001), FVC (r = −0.440, p = 0.004), %FVC (r =−0.539, p < 0.001), DLco (r =−0.394, p = 0.018), and %DLco (r =−0.413, p = 0.008) and a positive correlation with KL-6 (r = 0.432, p = 0.005) were found for p-cymene. Conclusion: We found characteristic 5 VOCs in the exhaled breath of IPF patients. Among them, the VOC peaks of p-cymene were related to the clinical parameters of IPF. These VOCs may be useful biomarkers of IPF.

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Metadaten
Author of HS ReutlingenBaumbach, Jörg Ingo
DOI:https://doi.org/10.1007/s00408-017-9979-3
ISSN:0341-2040
eISSN:1432-1750
Erschienen in:Lung
Publisher:Springer
Place of publication:Berlin, Heidelberg
Document Type:Article
Language:English
Year of Publication:2017
Tag:exhaled breath; idiopathic pulmonary fibrosis; ion mobility spetrometer; multi-capillary column; volatile organic compound
Volume:195
Issue:2
Page Number:8
First Page:247
Last Page:254
DDC classes:610 Medizin, Gesundheit
Open Access?:Nein
Licence (German):License Logo  Lizenzbedingungen Springer