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Adherence of volatile propofol to various types of plastic tubing

  • Propofol is an intravenous anesthetic. Currently, it is not possible to routinely measure blood concentration of the drug in real time. However, multi-capillary column ion-mobility spectrometry of exhaled gas can estimate blood propofol concentration.Unfortunately, adhesion of volatile propofol on plastic materials complicates measurements. Therefore, it is necessary to consider the extent to which volatile propofol adheres to various plastics used in sampling tubing. Perfluoralkoxy (PFA), polytetrafluorethylene (PTFE), polyurethane (PUR), silicone, and Tygon tubing were investigated in an experimental setting using a calibration gas generator (HovaCAL). Propofol gas was measured for one hour at 26 °C, 50 °C, and 90 °C tubing temperature. Test tubing segments were then flushed with N2 to quantify desorption. PUR and Tygon sample tubing absorbed all volatile propofol. The silicone tubing reached the maximum propofol concentration after 119 min which was 29 min after propofol gas exposure stopped. The use of PFAor PTFE tubing produced comparable and reasonably accurate propofol measurements. The desaturation time for the PFA was 10 min shorter at 26 °C than for PTFE. PFA tubing thus seems most suitable for measurement of volatile propofol,with PTFE as an alternative.

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Metadaten
Author of HS ReutlingenPielsticker, Gianluca; Baumbach, Jörg Ingo
DOI:https://doi.org/10.1088/1752-7163/aa567e
ISSN:1752-7163
eISSN:1752-7163
Erschienen in:Journal of breath research : volatiles for medical diagnosis ; official journal of the International Association for Breath Research (IABR) and the International Society for Breath Odor Research (ISBOR)
Publisher:IOP
Place of publication:Bristol
Document Type:Article
Language:English
Year of Publication:2017
Tag:breath analysis; drug monitoring; ion mobility spectrometry; propofol
Volume:11
Issue:1
Page Number:6
First Page:1
Last Page:6
DDC classes:610 Medizin, Gesundheit
Open Access?:Nein