The search result changed since you submitted your search request. Documents might be displayed in a different sort order.
  • search hit 3 of 23
Back to Result List

Elastic free energy drives the shape of prevascular solid tumors

  • It is well established that the mechanical environment influences cell functions in health and disease. Here, we address how the mechanical environment influences tumor growth, in particular, the shape of solid tumors. In an in vitro tumor model, which isolates mechanical interactions between cancer tumor cells and a hydrogel, we find that tumors grow as ellipsoids, resembling the same, oft-reported observation of in vivo tumors. Specifically, an oblate ellipsoidal tumor shape robustly occurs when the tumors grow in hydrogels that are stiffer than the tumors, but when they grow in more compliant hydrogels they remain closer to spherical in shape. Using large scale, nonlinear elasticity computations we Show that the oblate ellipsoidal shape minimizes the elastic free energy of the tumor-hydrogel system. Having eliminated a number of other candidate explanations, we hypothesize that minimization of the elastic free energy is the reason for predominance of the experimentally observed ellipsoidal shape. This result may hold significance for explaining the shape progressio.

Download full text files

Export metadata

Additional Services

Share in Twitter Search Google Scholar
Metadaten
Name:Kemkemer, Ralf
URN:urn:nbn:de:bsz:rt2-opus4-780
DOI:https://doi.org/10.1371/journal.pone.0103245
ISSN:1932-6203
Erschienen in:PLoS one
Publisher:PLoS
Place of publication:Lawrence, Kanada
Document Type:Article
Language:English
Year of Publication:2014
Volume:9
Issue:7
Pagenumber:8
First Page:1
Last Page:7
Dewey Decimal Classification:610 Medizin, Gesundheit
Open Access:Ja
Licence (German):License Logo  Creative Commons - Namensnennung