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Drug release from liposome coated hydrogels for soft contact lenses: the blinking and temperature effect

  • In this article, liposome-based coatings aiming to control drug release from therapeutic soft contact lenses (SCLs) materials are analyzed. A PHEMA based hydrogel material loaded with levofloxacin is used as model system for this research. The coatings are formed by polyelectrolyte layers containing liposomes of 1,2-dimyristoyl-sn-glycero-3- phosphocholine (DMPC) and DMPC1cholesterol (DMPC1 CHOL). The effect of friction and temperature on the drug release is investigated. The aim of the friction tests is to simulate the blinking of the eyelid in order to verify if the SCLs materials coated with liposomes are able to keep their properties, in particular the drug release ability. It was observed that under the study conditions, friction did not affect significantly the drug release from the liposome coated PHEMA material. In contrast, increasing the temperature of release leads to an increase of the drug diffusion rate through the hydrogel. This phenomenon is recorded both in the control and in the coated samples.

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Metadaten
Name:Krastev, Rumen
DOI:https://doi.org/10.1002/jbm.b.33715
ISSN:1552-4973
eISSN:1552-4981
Erschienen in:Journal of biomedical materials research. - Part B. Applied biomaterials
Publisher:Wiley
Place of publication:Hoboken, NJ
Document Type:Article
Language:English
Year of Publication:2017
Tag:drug release; eyelid; friction; liposomes; soft contact lenses
Volume:105
Issue:7
Pagenumber:9
First Page:1799
Last Page:1807
Dewey Decimal Classification:570 Biowissenschaften, Biologie
Open Access:Nein
Licence (German):License Logo  Lizenzbedingungen Wiley