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Design of intelligent chitosan/heparin hollow microcapsules for drug delivery

  • In this study, a novel strategy has been developed for the assembly of polyelectrolyte multilayer (PEM) on CaCO3 templates in acidic pH solutions, where consecutive polyelectrolyte layers (heparin/poly(allylamine hydrochloride) or heparin/chitosan) were deposited on PEM hollow microcapsules established previously on CaCO3 templates. The PEM build-up, hollow capsule characterization and successful encapsulation of fluorescein 5(6)-isothiocyanate (FITC)-Dextran by coprecipitation with CaCO3 are demonstrated. Improvement by the removal of CaCO3 core was achieved while the depositions. In the course of the release profile, high retardation for encapsulated FITC-Dextran was observed. The combined shell capsules system is a significant trait that has potential use in tailoring functional layer-by-layer capsules as intelligent drug delivery vehicles where the preliminary in vitro tests showed the responsiveness on the enzymes.

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Metadaten
Name:Krastev, Rumen
DOI:https://doi.org/10.1002/app.44425
ISSN:0021-8995
eISSN:1097-4628
Erschienen in:Journal of applied polymer science
Publisher:Wiley
Place of publication:New York, NY
Document Type:Article
Language:English
Year of Publication:2017
Tag:biomedical applications; drug delivery systems; polyelectrolytes
Volume:134
Issue:5
Pagenumber:10
First Page:1
Last Page:10
Dewey Decimal Classification:540 Chemie
Open Access:Nein
Licence (German):License Logo  Lizenzbedingungen Wiley