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Inversely 3D-printed β-TCP scaffolds for bone replacement

  • The aim of this study was to predefine the pore structure of β-tricalcium phosphate (β-TCP) scaffolds with different macro pore sizes (500, 750, and 1000 µm), to characterize β-TCP scaffolds, and to investigate the growth behavior of cells within these scaffolds. The lead structures for directional bone growth (sacrificial structures) were produced from polylactide (PLA) using the fused deposition modeling techniques. The molds were then filled with β-TCP slurry and sintered at 1250° C, whereby the lead structures (voids) were burnt out. The scaffolds were mechanically characterized (native and after incubation in simulated body fluid (SBF) for 28 d). In addition, biocompatibility was investigated by live/dead, cell proliferation and lactate dehydrogenase assays.

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Metadaten
Name:Lange, Svenja; Krastev, Rumen
URN:urn:nbn:de:bsz:rt2-opus4-25486
DOI:https://doi.org/10.3390/ma12203417
ISSN:1996-1944
Erschienen in:Materials / Molecular Diversity Preservation International
Publisher:MDPI
Place of publication:Basel
Document Type:Article
Language:English
Year of Publication:2019
Tag:FDM; bone replacement; inversely; β-TCP
Volume:12
Issue:20, 3417
Pagenumber:17
First Page:1
Last Page:17
Dewey Decimal Classification:600 Technik, Medizin, angewandte Wissenschaften
Open Access:Ja
Licence (German):License Logo  Creative Commons - CC BY - Namensnennung 4.0 International